Systematic evaluation of gene variants linked to hearing loss based on allele frequency threshold and filtering allele frequency

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

evaluating allele frequency and polymorphism of microsatellite markers linked to gene loci controlling rice grain quality

in this research, allele frequency and polymorphism of 27 microsatellite markers linked to gene loci controlling grain quality were determined between 47 rice varieties from four different groups including 21 iranian local, 16 improved, 7 irri and 3 upland rice varieties. average number of polymorphic information content (pic) and shannon’s diversity index were 0.54 and 1.14, respectively. maxi...

متن کامل

Allele Frequency of CYP2C19 Gene Polymorphisms in a Healthy Iranian Population

Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and inter-ethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic re-sponses and adverse drug reactions may vary from one person to another. In this stud...

متن کامل

Properties of neutrality tests based on allele frequency spectrum

One of the main necessities for population geneticists is the availability of statistical tools that enable to accept or reject the neutral Wright-Fisher model with high power. A number of statistical tests have been developed to detect specific deviations from the null frequency spectrum in different directions (i.e., Tajima’s D, Fu and Li’s F and D test, Fay and Wu’s H). Recently, a general f...

متن کامل

Evaluation of Allele Frequency Estimation Using Pooled Sequencing Data Simulation

Next-generation sequencing (NGS) technology has provided researchers with opportunities to study the genome in unprecedented detail. In particular, NGS is applied to disease association studies. Unlike genotyping chips, NGS is not limited to a fixed set of SNPs. Prices for NGS are now comparable to the SNP chip, although for large studies the cost can be substantial. Pooling techniques are ofte...

متن کامل

CSN1S1 Gene: Allele Frequency, and the Relationship with Milk Production Traits in Three Indigenous Cattle Breeds and Holstein

CSN1S1is one of the major genes encoding milk proteins of mammals. In this study we determined allele frequencies of CSN1S1-5` flanking region as well as exon 17 variants and their effects on milk traits in three indigenous cattle breeds Mazandarani, Golpaygani (Bos indicus) and Sarabi (Bos taurus) and Holstein cattle in Iran. CSN1S1*B variant was nearly fixed in Holstein but ranged from 0.40 t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Scientific Reports

سال: 2019

ISSN: 2045-2322

DOI: 10.1038/s41598-019-41068-6